CBD and Pain Relief
The human body makes its own version of CBD compounds called endocannabinoids with two receptors CB1 and CB2. They operate like neurotransmitters, switching on and off nerves. These, in turn, spark or dampen the electric pulse that creates thoughts, behaviours and movements. Tetrahydrocannabinoil (“THC”), the psychoactive substance that creates a high has a strong affinity to CB1, whereas CBD, with less than 0.2% THC does not typically interact with CB1 but can trigger a response to the body’s endocannabinoids. Researchers, including Dr Joseph Cheer, a neurobiologist at the University of Maryland who specialises in cannabinoids, suggest that CBD switches off electrical pulses associated with pain by tweaking the amount of calcium that can get inside the body’s nerves. (Source: Link)
Labskin has already successfully tested CBD demonstrating anti-microbial and anti-inflammatory effects in skin-care with the Company’s STOER For Men cosmetics products, and is currently testing CBD infused female hygiene products at the Company’s Labskin test facility in York, UK.
Chronic Wound Care Market Growth
The incidence of chronic wounds is growing with approximately 1–2% of the USA population sustaining chronic wounds during their lifetime, leading to approximately 6.5 million incidences at an annual cost of approximately US$25 billion. In Europe, wound management costs approximately €6650–€10,000 per patient and consumes 2–4% of European healthcare budgets.
Patients with diabetes are also at high risk of wound infections. Approximately 387 million people have diabetes, and this number is predicted to increase by 205 million by 2035.
The Collaboration Partners
Labskin (Innovenn Ltd – wholly owned subsidiary of Integumen)
Integumen’s laboratory grown human skin testing services. Specifically developed to host harmful bacteria on simulated human skin. It is the best testing platform for antimicrobial products, such as anti-dandruff shampoos and anti-acne creams, anti-aging, anti-fungal, UV sun exposure, toxic shock, and drug delivery through the skin, which cannot currently be carried out in vivo (animal models) due to ethical constraints of testing harmful bacteria.
Wound pHase (LifeScienceHub Limited – wholly owned subsidiary of Integumen)
Lifesciencehub’s lead technology is a pH diagnostic tool, WoundpHase, which has applications in the staging of chronic non-healing wounds, such as diabetic foot ulcers and venous stasis ulcers. Wound pHase is a polymer film in disc form which is applied to a wound and surrounding skin in the same way as a traditional hydrogel dressing. Responding to the acidity/alkalinity of the wound, the disc changes colour within five minutes of application. The colorimetric response of the disc to the wound indicates the acidity/alkalinity of the wound bed. Given that the pH of a chronic wound determines the ability of the wound to heal, Wound pHase allows caregivers to monitor the changing state of a wound, andtherefore vary the appropriate treatment regime.
The Cellulac plc (9.35% owned by Integumen) – www.cellulac.com
A patented oil extraction pricess that excludes the use of high temperature solvents, developed over 16 years with capacity of between 4 and 1,000 tonnes per hour. Has already been installed at commercial scale for extraction of Omega 3 with EU and US clearance for human consumption. Extraction rig has been installed at TCBB Resource facility in Thurles, Ireland specifically for this extraction process.
Dept. Chemical Sciences, University of Limerick – www.ul.ie
Using laboratory and pilot scale processing facilities to test and optimise the yield of selected product from characterised feedstocks. The goal of this project is to extend the development of novelty industrial and commercial products through optimising the process variables for particular feedstocks or products such as CBD from hemp.
Epitheal Limited – www.epitheal.com
Epitheal is a science driven dermatology company, researching and developing formulations to promote healthy skin focusing on conditions using natural compounds as the basis of their research such as salicylic acid. Epitheal also focus on the varying application of natural compounds treating a wide range of diseases worldwide
tcbb RESOURCE – Irish Research Centre for Resource Efficiency CLG – www.tcbbresource.ie
tcbb RESOURCE is an Irish Government supported not-for-profit, test-bed for bio-based innovation – scale-up, demonstration and pilot technology for resource recovery and renewable gas and collaborates with higher-education research groups, enterprises and state agencies in publicly-funded programmes to support industry in the transition towards a low-carbon economy.