University of Leeds – Immune Responses of a Living Skin Equivalent Model Colonized by Staphylococcus Epidermidis or Staphylococcus Aureus
The resident commensal microorganisms found on human skin are predominantly Gram-positive species. The commensal Staphylococcus epidermidis is the most prevalent staphylococcal species, whereas Staphylococcus aureus is a transient, opportunistic pathogen causing superficial as well as serious invasive infections.
Skin is the first line of defence against pathogens and understanding the interactions between the microbial communities and epidermis is essential. The surface of human skin is continually exposed to a variety of microorganisms/pathogens, but infections are not common in healthy individuals, suggesting the presence of a robust and effective cutaneous defence system.