FULL THICKNESS HUMAN SKIN

3D HUMAN SKIN MODEL ENGINEERED FOR ETHICAL TESTING AND R&D

FULL THICKNESS HUMAN SKIN

3D HUMAN SKIN MODEL ENGINEERED FOR ETHICAL TESTING AND R&D

Labskin is a full thickness human skin equivalent. Incorporating fully-differentiated dermal and epidermal components that functionally models skin, Labskin allows you to carry out high quality skin research and testing.

Whether you are conducting basic or applied skin research, testing compounds or formulated products from the cosmetic, pharmaceutical or chemical sectors, Labskin offers you a high-quality, convenient, reliable and reproducible living skin model.

  • Labskin can be colonised with skin microflora.
  • Labskin mimics real human skin biome for real world results.

Labskin is a full thickness human skin equivalent. Incorporating fully-differentiated dermal and epidermal components that functionally models skin.

Whether you are conducting basic or applied skin research, testing compounds or formulated products from the cosmetic, pharmaceutical or chemical sectors, Labskin offers you a high-quality, convenient, reliable and reproducible living skin model.

  • Labskin can be colonised with skin microflora

  • Labskin mimics real human skin biome for real world results.

12 YEARS DEVELOPMENT

DESIGNED BY SKIN SCIENTISTS

Labskin is the product of 12 years of development work. Designed by skin scientists to provide a living skin equivalent with superior robustness and longevity, Labskin’s large surface area and strength make it suitable for a wide range of research and test applications.

Made from metabolically-active primary human fibroblasts and keratinocytes which conduct paracrine signalling, Labskin more closely reproduces the in-vivo environment compared to monolayer cultures or ex-vivo skin models.

About Us

HUMAN SKIN EQUIVALENT

DESIGNED FOR SKIN MICROBIOLOGY

Uniquely for a skin equivalent model, Labskin can be colonised with the microflora of skin to provide a life-like platform for the study of microbiological systems or the influence of antimicrobials.

Using either commensal skin microflora or known pathogenic strains, you can simultaneously gauge both cellular and microbial responses to your product.

Download application highlights [.PDF 449KB]

Skin Testing

12 YEARS DEVELOPMENT

DESIGNED BY SKIN SCIENTISTS

Labskin is the product of 12 years of development work. Designed by skin scientists to provide a living skin equivalent with superior robustness and longevity, Labskin’s large surface area and strength make it suitable for a wide range of research and test applications.

Made from metabolically-active primary human fibroblasts and keratinocytes which conduct paracrine signalling, Labskin more closely reproduces the in-vivo environment compared to monolayer cultures or ex-vivo skin models.

About Us

HUMAN SKIN EQUIVALENT

DESIGNED FOR SKIN MICROBIOLOGY

Uniquely for a skin equivalent model, Labskin can be colonised with the microflora of skin to provide a life-like platform for the study of microbiological systems or the influence of antimicrobials.

Using either commensal skin microflora or known pathogenic strains, you can simultaneously gauge both cellular and microbial responses to your product.

Skin Testing

WHY IS LABSKIN DIFFERENT?

Uniquely for a skin equivalent model, Labskin can be colonised with the microflora of skin to provide a life-like platform for the study of microbiological systems or the influence of antimicrobials. Using either commensal skin microflora or known pathogenic strains, you can simultaneously gauge both cellular and microbial responses to your product.

Labskin can be colonised with the microflora of skin to provide a life-like platform for the study of microbiological systems.

SKIN COLONISATION

View Skin Tests

SKIN COLONISATION

Dermatophytes T Rubrum on Skin
Dermatophytes (T. rubrum)

Antifungal effect in colonization of Labskin by Dermatophytes.

Malassezia Globosa on SKin
Malassezia globosa

Antidandruff effect in colonization of Labskin with Malassezia.

Malassezia Globosa Comensal Microflora Mix
Malassezia globosa + Comensal Microflora

Antidandruff effect in colonisation of Labskin with Malassezia and a comensal microbial consortium.

Staphylococcus on skin
Staphylococci

Testing for dysbiosis in Eczema.

C. Acnes Skin Colonisation
Acne vulgaris

Acne-related infection by C. acnes.

Wounds Colonised C Albicans S Aureus
Wounds

Antiseptic/Antimicrobial testing in wounds colonised by interkingdom biofilms (S. aureus + C. albicans).

Dermatophytes T Rubrum on Skin
Dermatophytes (T. rubrum)

Antifungal effect in colonization of Labskin by Dermatophytes.

Malassezia Globosa on SKin
Malassezia globosa

Antidandruff effect in colonization of Labskin with Malassezia.

Malassezia Globosa Comensal Microflora Mix
Malassezia globosa + Comensal Microflora

Antidandruff effect in colonisation of Labskin with Malassezia and a comensal microbial consortium.

Staphylococcus on skin
Staphylococci

Testing for dysbiosis in Eczema.

C. Acnes Skin Colonisation
Acne vulgaris

Acne-related infection by C. acnes.

Wounds Colonised C Albicans S Aureus
Wounds

Antiseptic/Antimicrobial testing in wounds colonised by interkingdom biofilms (S. aureus + C. albicans).

MULTI-LAYERED SKIN SUBSTITUTE

IMPROVED BARRIER FUNCTION

As a fully-differentiated, multi-layered human skin substitute with a complete basement membrane, Labskin displays a barrier function similar to that of human skin.

Labskin’s dry surface presents a physical protective barrier to the cells beneath. Electrical impedance and Transepidermal Water Loss (TEWL), used to quantify the integrity of the skin’s barrier function, show Labskin as an excellent model to substitue human skin.

Watch the Video

BEHAVES JUST LIKE HUMAN SKIN

STRONG AND ROBUST TISSUE

Labskin looks, feels and behaves just like human skin. It’s life-like surface is dry and anchored, making it significantly stronger and easier to handle than other commercially available skin models.

With a surface area of 4.5cm2, Labskin’s size and strength allows realistic product application such as repeated finger-spreading. Labskin can be sampled as you would in the clinic, withstanding tape-stripping, scrub-washing and multiple punch biopsies.

SKin Tests

MULTI-LAYERED SKIN SUBSTITUTE

IMPROVED BARRIER FUNCTION

As a fully-differentiated, multi-layered human skin substitute with a complete basement membrane, Labskin displays a barrier function similar to that of human skin.

Labskin’s dry surface presents a physical protective barrier to the cells beneath. Electrical impedance and Transepidermal Water Loss (TEWL), used to quantify the integrity of the skin’s barrier function, show Labskin as an excellent model to substitue human skin.

Watch the Video

BEHAVES JUST LIKE HUMAN SKIN

STRONG AND ROBUST TISSUE

Labskin looks, feels and behaves just like human skin. It’s life-like surface is dry and anchored, making it significantly stronger and easier to handle than other commercially available skin models.

With a surface area of 4.5cm2, Labskin’s size and strength allows realistic product application such as repeated finger-spreading. Labskin can be sampled as you would in the clinic, withstanding tape-stripping, scrub-washing and multiple punch biopsies.

Download the Labskin spec [.PDF 56KB]

Skin Testing

MULTI-LAYERED SKIN SUBSTITUTE

APPLICATIONS

  • Basic and applied skin research

  • Structural, metabolic and physiological studies

  • Microbial colonisation
  • Pre-clinical screening

  • Ingredient and product efficiency

  • Gene and protein expression

  • Penetration and delivery

Skin Tests

FEATURES

  • Fully differentiated and multi-layered skin model

  • Dermal and epidermal components

  • Metabolically active primary human skin cells

  • De novo collagen production

  • Ready to use, easy to handle format

  • Skin-like surface and strength

  • Large test area (4.5cm2)
  • Barrier function similar to native skin

  • 10+ day test window

  • Uniform, high quality and reproducible tissues

  • The large size allows for multiple tests

Constructed from pooled normal primary adult human fibroblasts and neonatal foreskin primary human keratinocytes.

Substantially improved strength and barrier integrity due to the novel method of construction of the dermis using polymerised fibrin as the supporting matrix, naturally anchored to a plastic insert for ease of manipulation and handling.

The entire dermal matrix being secreted by the fibroblasts in the dermal compartment creates a fully natural and complex mix of extracellular matrix (ECM) proteins.

The significantly improved robustness makes Labskin compatible with many standard application and sampling protocols, making it useable in a wider range of applications than other models.

View Applications

MULTI-LAYERED SKIN SUBSTITUTE

APPLICATIONS

  • Basic and applied skin research

  • Structural, metabolic and physiological studies

  • Microbial colonisation
  • Pre-clinical screening
  • Ingredient and product efficiency
  • Gene and protein expression
  • Penetration and delivery
Skin Tests

FEATURES

  • Fully differentiated and multi-layered skin model

  • Dermal and epidermal components

  • Metabolically active primary human skin cells

  • De novo collagen production

  • Ready to use, easy to handle format

  • Skin-like surface and strength

  • Large test area (4.5cm2)
  • Barrier function similar to native skin

  • 10+ day test window

  • Uniform, high quality and reproducible tissues

  • The large size allows for multiple tests

Constructed from pooled normal primary adult human fibroblasts and neonatal foreskin primary human keratinocytes.

Substantially improved strength and barrier integrity due to the novel method of construction of the dermis using polymerised fibrin as the supporting matrix, naturally anchored to a plastic insert for ease of manipulation and handling.

The entire dermal matrix being secreted by the fibroblasts in the dermal compartment, creates a fully natural and complex mix of extracellular matrix (ECM) proteins.

The significantly improved robustness makes Labskin compatible with many standard application and sampling protocols, making it useable in a wider range of applications than other models.

View Applications