The high cost of drug discovery failures has led to the development of 3D in vitro models. These allow cells to grow or interact with their three-dimensional surroundings. The cells are embedded within an artificial scaffold to mimic the life-like environment of testing on living tissue.
Numerous studies have shown cells grown within 3D in-vitro models to be physiologically relevant and retain an improved biological functionality.
3D cells in these models mimic in-vivo:
- Cellular morphology
- Response to stimuli
- Drug metabolism
- Gene expression
- Protein synthesis
- General cell function
What does Labskin 3D allow you to achieve?
- Induction of psoriatic skin by mimicking the inflammatory response
- Induction of atopic dermatitis-like features
- Modified skin cultures to mimic melanoma (a type of skin cancer)
The addition of human malignant melanoma cells with the keratinocytes within the model has been shown to closely follow the progression of melanoma in-vivo.
- These realistic diseased models provide a robust platform to study
- They offer a greater understanding of these diseases
- They are a tool to develop therapeutic treatments for these conditions
Labskin provides a more realistic three-dimensional environment that is able to provide a more appropriate representation of biological responses when compared to living human skin.
No compound is unique, so why should all 3D in-vitro models be the same. Standard or bespoke, Labskin models will solve your development problem. Call or email now and tell us what you want help with.