A recent study at the Jackson Laboratory for Genomic Medicine independently tested Labskin’s full thickness human skin model, further validating our expertise in the skin microbiome.
Labskin’s 15 years of laboratory skin science expertise is invaluable in providing Skin Trust Club members with unbiased, scientifically-tested skincare product recommendations tailored to their individual skin needs. An at-home microbiome skin swab test combined with powerful bioinformatics, AI algorithms and our extensive knowledge of the skin microbiome allows for a truly personalised customer experience.
How Does Labskin Compare?
A recent study at the Jackson Laboratory for Genomic Medicine independently tested Labskin’s full thickness human skin model, further validating our expertise in the skin microbiome. The Jackson Laboratory offer an unbiased comparison of three commercially available human model systems for skin microbiome research applications, in which Labskin comes out on top.
According to the study, one 3D human skin equivalent provider, MatTek, produces EpiDerm which is comprised of reconstructed human epidermis (RHE) differentiated from human foreskin-derived epidermal keratinocytes. Labskin is not an RHE but a full-thickness skin equivalent (HSE) with dermis and epidermis. This means Labskin is better suited to supporting the skin’s natural microflora, partly due to an additional thick dermal matrix constructed from fibroblasts. The third model system investigated was Genoskin’s NativeSkin which are skin biopsies from living human donors.
In order to compare the performance of each system when modelling skin microbiota, four common skin commensals were applied (Corynebacterium, Micrococcus, Cutibacterium and Staphylococcus). After allowing the bacterial communities to equilibrate for 5-7 days, samples were collected for colony forming unit (CFU) analysis, qPCR and 16S rRNA sequencing. The predicted microorganisms were detected on all models with composition varying between models, as well as by donor in the case of NativeSkin biopsies.