Published Paper

Challenges Developing a Human Model System for Skin Microbiome Research

Challenges Developing a Human Model System for Skin Microbiome Research

The human skin is colonized by a diversity of microorganisms. The human skin microbiome has come into great interest for its role in skin health and disease, and as a potential target for therapeutic and cosmetic applications (Byrd et al. 2018). A major limitation in the laboratory investigation of microbial and host-microbe interactions on human skin is the lack of a model that can reliably reproduce the complexity of the host. Attempts to model human microbial communities in rodents are impeded by competition from native flora, and even germ-free models suffer due to the substantial differences between murine and human integumentary systems.

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