On April 5th, 2017 the EU formally approved the new Medical Devices Regulation, replacing the two existing directives – the Medical Devices Directive, and the Active Implantable Medical Devices Directive.
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One of the most important ethical issues facing the skincare market in the 21st century is the overwhelming pressure being received from International Governments and animal-rights organisations to develop and test new cosmetics or skincare products that do not involve animal testing as part of any test procedures.
International Journal of Cosmetic Science – 2018 Examination of the Skin Barrier Repair Wound Healing Processadmin2019-07-10T12:36:10+01:00
Damage to the structural integrity of the skin through trauma or injury initiates the skin barrier repair/wound healing process, which is highly complex and carefully regulated with ordered responses. There are four main stages involved in the normal skin barrier repair/wound healing process: haemostasis, inflammation, proliferation and remodelling, all of which occur in an over-lapping chronological sequence.
A 3D cell culture is an artificially created environment in which cells are permitted to grow/interact with their surroundings in all three dimensions. Derived from 3D cell culture, organoids are generally small-scale constructs of cells that are fabricated in the laboratory to serve as 3D representations of in vivo tissues and organs.
3D human skin models are the latest tool in non-animal testing for the skincare and cosmetic markets. Human synthetic skin models are the most physiologically comparable to natural human skin testing methods available, with the added benefit of being cruelty-free to animals.
In-vitro models are important tools for biological research and cell-based assays are used to predict drug activity, metabolism, and toxicity in-vivo.
Elsevier Journal – Lipid Changes in Living Skin Equivalents in Response to Creams Containing Palmitoylethanolamideadmin2019-07-10T12:36:21+01:00
Whilst many immunohistochemistry, autoradiography and spectroscopic methods are routinely used in dermatological research, the application of MALDI MSI is still relatively new. One of the key features of MALDI MSI that makes its use appealing is the ability to detect and study the distribution of multiple compounds simultaneously in a label-free manner.